Transport inhibition occurs at clinically relevant concentrations.

Values are shown as mean (Cm; concentration determined in this study), highest mean/median (Cu) and maximal uremic concentration (Cmax). Both Cu and Cmax were obtained from www.uremic-toxins.org, unless stated otherwise. IC50 and IC20 values are shown as mean ± SEM of three separate experiments performed in triplicate.aCu obtained from literature [33].bHypothetical Cmax, calculated as Cmax = Cu + 2 SD, as previously described [19].cKi for competitive inhibition.数据以均值形式呈现，其中Cm（本研究测定的浓度）、Cu（最高均值/中位数）以及Cmax（最大尿毒症浓度）。除非另有说明，Cu与Cmax均取自www.uremic-toxins.org网站。半最大抑制浓度（half maximal inhibitory concentration, IC50）与20%抑制浓度（20% inhibitory concentration, IC20）的数值，以三次独立实验（每次均设置三次复孔）所得的均值±标准误（Standard Error of the Mean, SEM）表示。 a：Cu数据取自文献[33]。 b：假设性Cmax，按照此前报道[19]的方法计算得到，计算公式为Cmax = Cu + 2倍标准差（Standard Deviation, SD）。 c：竞争性抑制的抑制常数（inhibition constant, Ki）。