Spatial transcriptomics data of mouse thymus

The thymus is a critical organ for T cell development and immune system function, but it undergoes significant structural and functional changes during aging, a process known as thymic involution. To investigate the spatial and cellular changes associated with thymic aging, we performed single-cell spatial transcriptomics on thymic tissues from young (4-week-old) and aged (52-week-old) C57BL/6J mice, with three biological replicates per age group. This dataset provides a detailed spatial and cellular map of the thymus at single-cell resolution, capturing changes in cell types, abundances, and spatial organization during aging. The results offer valuable insights into the cellular and spatial heterogeneity of the thymus and provide a resource for understanding immune system aging and potential therapeutic strategies.