The crystal structure of spermidine synthase from p. falciparum in complex with AdoDATO

The crystal structure of spermidine synthase from p. falciparum in complex with AdoDATO Descriptor: 2-(2-{2-[2-(2-METHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHANOL, GLYCEROL, S-ADENOSYL-1,8-DIAMINO-3-THIOOCTANE, ... Authors: Qiu, W, Dong, A, Ren, H, Wu, H, Wasney, G, Vedadi, M, Lew, J, Kozieradski, I, Edwards, A.M, Arrowsmith, C.H, Weigelt, J, Sundstrom, M, Plotnikov, A.N, Bochkarev, A, Hui, R, Structural Genomics Consortium (SGC) Deposit date: 2006-08-30 Release date: 2006-09-12 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (1.71 Å) Cite: Crystal structure of Plasmodium falciparum spermidine synthase in complex with the substrate decarboxylated S-adenosylmethionine and the potent inhibitors 4MCHA and AdoDATO. J.Mol.Biol., 373, 2007

恶性疟原虫（Plasmodium falciparum）来源的亚精胺合酶（spermidine synthase）与AdoDATO复合物的晶体结构，配体信息如下：2-(2-{2-[2-(2-甲氧基乙氧基)乙氧基]乙氧基}乙氧基)乙醇、甘油、S-腺苷-1,8-二氨基-3-硫代辛烷等。作者：Qiu W、Dong A、Ren H、Wu H、Wasney G、Vedadi M、Lew J、Kozieradski I、Edwards AM、Arrowsmith CH、Weigelt J、Sundstrom M、Plotnikov AN、Bochkarev A、Hui R，以及结构基因组学联盟（Structural Genomics Consortium, SGC）。提交日期：2006-08-30；发布日期：2006-09-12；最后修改日期：2023-08-30。实验方法：X射线衍射（X-RAY DIFFRACTION，分辨率1.71 Å）。引用文献：《恶性疟原虫亚精胺合酶与底物脱羧S-腺苷甲硫氨酸及强效抑制剂4MCHA和AdoDATO的复合物晶体结构》，《Journal of Molecular Biology》（简称J.Mol.Biol.），2007年，第373卷。