Structure of p110 gamma bound to the Ras inhibitory nanobody NB7

Structure of p110 gamma bound to the Ras inhibitory nanobody NB7 Descriptor: Nanobody NB7, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform Authors: Burke, J.E, Nam, S.E, Rathinaswamy, M.K, Yip, C.K. Deposit date: 2022-07-14 Release date: 2023-07-19 Last modified: 2025-06-04 Method: ELECTRON MICROSCOPY (2.96 Å) Cite: Allosteric activation or inhibition of PI3K gamma mediated through conformational changes in the p110 gamma helical domain. Elife, 12, 2023结合Ras抑制性纳米抗体NB7的p110γ蛋白结构 描述：纳米抗体NB7、磷脂酰肌醇-4,5-二磷酸3-激酶催化亚基γ亚型（Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform） 作者：Burke, J.E.、Nam, S.E.、Rathinaswamy, M.K.、Yip, C.K. 存储日期：2022-07-14 发布日期：2023-07-19 最后修改日期：2025-06-04 实验方法：电子显微镜法（分辨率2.96埃） 引用文献：通过p110γ螺旋结构域的构象变化介导PI3Kγ的变构激活或抑制，《eLife》，12卷，2023年