Case-control based association of chromosome 9p21 with CAD.

Ordinary logistic regression in an additive model was calculated for combined subsets of CAD adjusted to major risk factors of atherosclerosis (age, gender, smoking, diabetes, HDL-C- and LDL-C-levels adjusted for statin treatment). Analyses of myocardial infarction were only adjusted for age, gender, smoking, diabetes, but not for HDL-C and LDL-C, because the latter parameters significantly change during the acute event. ORs are given per allele.针对经动脉粥样硬化主要危险因素校正的冠状动脉疾病（Coronary Artery Disease, CAD）合并亚组，本研究采用加性模型下的普通逻辑回归开展分析，校正因素涵盖年龄、性别、吸烟、糖尿病、高密度脂蛋白胆固醇（High-Density Lipoprotein Cholesterol, HDL-C）及低密度脂蛋白胆固醇（Low-Density Lipoprotein Cholesterol, LDL-C）水平，且上述血脂指标已根据他汀类药物治疗情况进行校正。针对心肌梗死的分析仅校正了年龄、性别、吸烟与糖尿病四项变量，未纳入HDL-C与LDL-C，原因在于后者在急性发作期会发生显著变化。所有比值比（Odds Ratios, ORs）均以每等位基因作为单位进行报告。