Accessing 1,3-Dienes via Palladium-Catalyzed Allylic Alkylation of Pronucleophiles with Skipped Enynes

An unprecedented palladium-catalyzed
allylic alkylation of pronucleophiles
with unactivated skipped enynes has been developed. This method provides
a straightforward access to a wide array of 1,3-dienes without the
need to preinstall leaving groups or employ extra oxidants. The reaction
exhibited high atom economy, good functional group tolerance, excellent
regioselectivities, and scalability. With D2O as cosolvent,
deuterium could be incorporated in high efficiency.