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mTORC1 inhibition activates the integrated stress response (ISR) in TALL-1 cell line

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NIAID Data Ecosystem2026-05-02 收录
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mTOR sensitized T-ALL cell lines and patient-derived xenografts (PDX) from patients with R/R T-ALL to the BCL-2 inhibitor Venetoclax. Overall design: TALL-1 cells were treated with vehicle or 10 µM Everolimus for 4 and 12 hours in presence or absence of ISRIB. RNAseq was performed on each samples.

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2025-08-14
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