File S1 - Pharmacological and Molecular Effects of Platinum(II) Complexes Involving 7-Azaindole Derivatives

Supporting information. The 1H, 13C, 15N and 195Pt NMR data assigned to trans-[PtCl2(naza)2] complexes (1t, 2t, 3t) detected as an impurity of the studied cis-[PtCl2(naza)2] complexes, the 1H, 13C, 15N and 195Pt NMR data for the products of hydrolysis of 1 and 3 in DMF-d7/H2O mixture (1 h and 3 h). Figure S1. The ESI-mass spectrum of the mixture of the complex 1 with cysteine and glutathione measured one month after the mixing of the components. Figure S2. ITC results showing the heat released during the titration of cysteine, GSH and HSA by 1 or cisplatin and the binding isotherms. Figure S3. The effect of 1–3 and cisplatin on MMPs secretion in isolated tumours. Figure S4. The effect of 1–3 and cisplatin on VEGF-A secretion in isolated tumours. Table S1. The values of logIC50 (µM) for the complexes 1–3 and cisplatin.
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