Psenen

Enables endopeptidase activator activity. Involved in positive regulation of endopeptidase activity and protein processing. Acts upstream of or within Notch receptor processing. Part of gamma-secretase complex. Is expressed in early tubule; female associated reproductive structure; male associated reproductive structure; ovary; and testis. Human ortholog(s) of this gene implicated in hidradenitis suppurativa. Orthologous to human PSENEN (presenilin enhancer, gamma-secretase subunit). [provided by Alliance of Genome Resources, Nov 2024]激活内肽酶激活剂活性，参与内肽酶活性和蛋白质加工的正向调控。位于Notch受体加工的上游或其中。是γ-分泌酶复合体的一部分。在早期肾小管、雌性相关生殖结构、雄性相关生殖结构、卵巢和睾丸中表达。该基因的人类同源基因与痤疮性汗腺炎相关。与人类PSENEN（前蛋白转化酶增强子，γ-分泌酶亚单位）同源。[由基因组资源联盟提供，2024年11月]