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A novel APP knock-in mouse model reveals profound metabolic perturbations in phagocytic microglia

NIAID Data Ecosystem2026-05-02 收录

阿尔茨海默病模型

小胶质细胞代谢

数据链接：

https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE158156 数据链接链接失效反馈

官方服务：

资源简介：

This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

应用场景：

创建时间：

2025-02-02

阿尔茨海默病模型

星形胶质细胞代谢

Supplementary files for article "Altered metabolic function induced by Aβ-oligomers and PSEN1 mutations in iPSC-derived astrocytes"Altered energy metabolism in Alzheimer's disease (AD) is a major path

Figshare2024-12-18 更新60

Additional file 3 of Translational profiling identifies sex-specific metabolic and epigenetic reprogramming of cortical microglia/macrophages in APPPS1-21 mice with an antibiotic-perturbed-microbiome

阿尔茨海默病模型

微生物组-免疫交互

Additional file 3.

Figshare2024-08-18 更新40

Additional file 12 of Novel App knock-in mouse model shows key features of amyloid pathology and reveals profound metabolic dysregulation of microglia

淀粉样蛋白病理

小胶质细胞代谢

Additional file 12: Table s4. Gene Sets in Figure 3 and Figure 4.

Figshare2022-06-11 更新40

Aging African Green Monkeys manifest transcriptional, pathological, and cognitive hallmarks of human Alzheimer’s disease

阿尔茨海默病模型

灵长类衰老转录组

While many preclinical models of Alzheimer’s disease (AD) have been reported, none fully recapitulate the disease. In an effort to identify an appropriate preclinical disease model, we characterized a

NIAID Data Ecosystem50

Additional file 7 of Influence of complement protein C1q or complement receptor C5aR1 on gut microbiota composition in wildtype and Alzheimer’s mouse models

阿尔茨海默病模型

微生物组

Additional file 7: Table S2. PERMANOVA results for main figures.

Figshare2024-08-16 更新40