Cytotoxic evaluation of natural and synthetic callipeltins: a revision of cytotoxicity of callipeltin B
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The cytotoxic evaluation of natural and synthetic callipeltins is described. Cyclic depsipeptide callipeltin B and linear peptides callipeltins E and M synthesized by us showed no cytotoxic activity. In contrast, natural callipeltin B purified from <i>Callipelta</i> sp. showed CC<sub>50</sub> = 130 μM against Hela cells. We found that purified callipeltin B included the contamination of callipeltins C and H at a ratio of approximately 15%. These results suggested that the cytotoxicity of natural callipeltin B was derived from callipeltins C and H.
创建时间：
2016-02-29
