Biochemical and larvicidal properties of the most potent PTFs.
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anumbers and groups refer to Table S1.
bIC50 values were determined from regression analysis of log-concentrations versus percentage inhibitions. RIC50 = IC50 WT/IC50 G119S. Compounds were sorted by their RIC50 ratio.
cMortality was measured from bioassays on Slab (OP-sensitive) and SR (OP-insensitive) strains exposed for 24 hours to 300 µM PTF. Rm300 = SR mortality/Slab mortality.
dPTFs biochemically characterized are in bold.
eHit compound from the primary screen.
fCompounds with RIC50 and Rm300 above 1.5.
创建时间：
2012-10-08
