Biochemical and larvicidal properties of the most potent PTFs.

anumbers and groups refer to Table S1. bIC50 values were determined from regression analysis of log-concentrations versus percentage inhibitions. RIC50 = IC50 WT/IC50 G119S. Compounds were sorted by their RIC50 ratio. cMortality was measured from bioassays on Slab (OP-sensitive) and SR (OP-insensitive) strains exposed for 24 hours to 300 µM PTF. Rm300 = SR mortality/Slab mortality. dPTFs biochemically characterized are in bold. eHit compound from the primary screen. fCompounds with RIC50 and Rm300 above 1.5.