MultipleMS MS Progression GWAS supporting material: Severity Scores of MS patients from Sweden

Meta-data for n=2751 MS cases from Sweden (European ancestry) that passed sample quality control and had at least one disability measure were included in the analysis. All participants gave written informed consent in accordance with approval from the relevant local ethical committees or institutional review boards. Patients with MS were ascertained and diagnosed by a neurologist locally according to established criteria. Neurological disability was measured using the EDSS29, an ordinal scale which incorporates a range of neurological functions relevant to MS. EDSS was scored by neurologist assessment. For each individual, the last recorded EDSS was converted to an ARMSS score by ranking disability against participants with the same age (±2 years) from the same cohort. The file includes the following metadata: SUBJECT_ID: Anonymized participant identifiers CENTER: The research center where the data was collected CHIP: The genotyping chip used SEX: Participant's sex AGE: Participant's age RINT_ARMSS: The RINT-ARMSS score, a measure of MS disease severity ANCESTRY: Participant's ancestry