B cell humoral response and differentiation is regulated by non-canonical poly(A) polymerase TENT5C.. B cell humoral response and differentiation is regulated by non-canonical poly(A) polymerase TENT5C.

Purpose: The goal of this study was to assess changes in the activated B cells transcriptome upon TENT5C knockout in mice Methods: RNA-Seq data were obtained for LPS-activated primary B cells isolated from either wild-type or TENT5C KO mice Results: Immunoglobulins transcripts were found to be downregulated in B cells isolated from TENT5C KO mice Overall design: mRNA profiles from activated B-cells from wild-type or TENT5C KO mice, generated by deep sequencing, in triplicate, using Illumina NextSeq 500.