Loci with highest LOD scores for a given subtype.

The highest LOD scores (shown in bold font), were obtained after including additional families (i.e., n2), as described in Table S2 in File S1. 1Previously reported linked region (see Table S1 in File S1 for references). *According to permutation tests reached a study-wide significant (i.e., p = 0.02, see Table S9A in File S3); G1 = 87% white, G1s = 98% white. aAn example of loci with highest LOD scores for the first level of subgrouping (intra-family heterogeneity included). This is potentially a shared linked region for all affected siblings in a pedigree regardless of concordance status, for a given subtype (i.e., G1). bLoci with highest LOD scores when only group-specific concordant autistic subjects were maintained (intra-family heterogeneity reduced). It is potentially a linked region only for concordant siblings in a given subtype (i.e., G1s and G4s).