SSTR2 in non-function and well-differentiated pNET

From June 2014 to January 2021, all non-functional pNET patients undergoing surgical resection with confirmed pathological results at Fudan University Shanghai Cancer Center (FUSCC) single center were retrospectively reviewed and 223 non-function and well-differentiated cases of pNET were enrolled in our cohort. Clinicopathological information was collected via the medical record database and pathologic examination notes. Expression of SSTR2 was detected via immunohistochemical staining of paraffin-embedded tissues with antibodies against SSTR2 according to standard IHC procedures. clinicopathological data was provided. Additionally, we report of rare case of multifocal pNET lesion with different SSTR2 status and we perform whole-exome sequencing on the two tumors. Sequencing results and variations after deduction of normal tissue were provided.2014年6月至2021年1月期间，本研究对复旦大学附属肿瘤医院（Fudan University Shanghai Cancer Center, FUSCC）单中心内所有接受手术切除且经病理确诊的无功能性胰腺神经内分泌肿瘤（pancreatic neuroendocrine tumor, pNET）患者进行回顾性分析，最终纳入223例无功能性、高分化pNET病例作为研究队列。临床病理信息通过医院电子病历数据库及病理检查记录完成收集。采用标准免疫组化（immunohistochemistry, IHC）操作流程，使用针对生长抑素受体2（somatostatin receptor 2, SSTR2）的抗体对石蜡包埋组织进行染色，以检测SSTR2的表达情况。本数据集包含完整的临床病理数据。此外，本研究还报告1例罕见的多灶性pNET病例，其两个病灶的SSTR2表达状态存在差异，并对这两个肿瘤实施了全外显子组测序（whole-exome sequencing, WES）。本数据集同步提供扣除正常组织后的测序结果及变异信息。