Gene expression profile of chemically induced expandable cardiovascular progenitor cells derived from mouse fibroblasts. Gene expression profile of chemically induced expandable cardiovascular progenitor cells derived from mouse fibroblasts

Cardiovascular progenitor cells (CPCs) can be reprogrammed from somatic fibroblasts by combinations of genes, providing a new avenue for cardiac regenerative therapy. Here we developed a strategy to capture chemically induced CPCs (ciCPCs) during the small molecule-induced cardiac reprogramming of mouse fibroblasts and expand these ciCPCs for a long-term in a chemically defined condition. RNA-seq analysis has been used to compare the expression profile of ciCPCs at early and late passages. Overall design: To study the characteristics of ciCPCs during their long-term expansion, we collected ciCPCs at both early (P3) and late (P20) passages.