Analysis of association between HIV disease history and Gag-specific CD8 T-cell proliferation in aviremic patients.

a Analysis was performed by logistic regressionb adjusted for variables included in the model. The following variables with P values c Virions using CCR5 as a coreceptor are referred to as R5 virions, whereas those CXCR4 as a coreceptor and dual-tropic viruses are referred to as X4R5 virionsd expressed in yearse expressed in log10 copies per 106 PBMCsf expressed as a percentage of total CD4 T cellsg expressed as a percentage of total CD8 T cellsh expressed as a percentage of naive CD4 T cellsi expressed in monthsj expressed in days x log10 HIV-RNA copies/ml of plasma.Analysis of association between HIV disease history and Gag-specific CD8 T-cell proliferation in aviremic patients.本研究采用针对模型中纳入变量进行校正的logistic回归（logistic regression）开展分析。以下为带有P值的相关变量：以CC趋化因子受体5（CC chemokine receptor 5, CCR5）作为共受体的病毒体（virions）称为R5型病毒体，以CXC趋化因子受体4（CXC chemokine receptor 4, CXCR4）作为共受体的病毒体及双嗜性病毒（dual-tropic viruses）则称为X4R5型病毒体；各指标的计量单位分别为：以年为单位；以每10^6个外周血单个核细胞（peripheral blood mononuclear cell, PBMC）的log10拷贝数为单位；以占总CD4阳性T细胞（CD4 T cells）的百分比为单位；以占总CD8阳性T细胞（CD8 T cells）的百分比为单位；以占初始CD4阳性T细胞（naive CD4 T cells）的百分比为单位；以月为单位；以天×血浆人类免疫缺陷病毒核糖核酸（HIV-RNA）的log10拷贝数/毫升为单位。本研究对病毒载量不可检测患者（aviremic patients）的HIV疾病史与Gag特异性CD8阳性T细胞增殖之间的关联进行了分析。