Dataset related to:"Prenylcysteine oxidase 1, a novel player in atherosclerosis "

This record contains raw data related to the article " Prenylcysteine oxidase 1, a novel player in atherosclerosis" Abstract The research into the pathophysiology of atherosclerosis has considerably increased our understanding of the disease complexity, but still many questions remain unanswered, both mechanistically and pharmacologically. We found that the pro-oxidant enzyme Prenylcysteine Oxidase 1 (PCYOX1), contributes to the oxidation of the lipoproteins, and it is transported within the subintimal space by proatherogenic lipoproteins accumulating in the arterial wall. PCYOX1 deficiency in apoE^-/- mice retards atheroprogression, is associated with decreased features of lesion vulnerability and lower levels of lipid peroxidation, improves plasma lipid profile, and reduces inflammation. Collectively, our findings identify a previously undiscovered biological role for PCYOX1 in atherogenesis.