Expression data of liver tissue from wild type and Cdc42 liver-specific knockout mice at 2-month-old. Expression data of liver tissue from wild type and Cdc42 liver-specific knockout mice at 2-month-old

Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related death. However, the mechanism for HCC initiation remains poorly known. Cdc42, a small Rho GTPase, with multiple cellular functions has been shown involved in variant types of human cancers, but its role in HCC initiation remains unclear. Cdc42 liver-specific knockout mice (Cdc42LK) developed HCC at 6-month-old. We used microarrays to detail the global programme of gene expression induced by Cdc42 deletion and identified distinct classes of up or down-regulated genes during HCC initial time. Overall design: The liver tissues of wild type and Cdc42LK mice were harvested at 2-month-old for RNA extraction and hybridization on Affymetrix microarrays. 4 biological replicates of wild type and Cdc42LK mice.