PREDICTIVE FACTORS FOR LOSS OF RESPONSE TO ANTI-TNF IN CROHN’S DISEASE

ABSTRACT Background: Anti-TNF drugs are a fundamental part of the treatment of Crohn’s disease (CD), so identifying factors related to loss of response is of great importance in clinical practice. Aim: Identify potential factors related to loss of response to anti-TNF agents in Crohn’s disease patients. Methods: This is a prospective study of CD patients attending a specialized outpatient clinic using a specific form, including patients with more than one year of follow-up on anti-TNF (Infliximab, Adalimumab or Certolizumab pegol). The information obtained was tabulated and analyzed to identify possible reasons for the loss of response to anti-TNF agents; results were submitted to statistical analysis by chi-square teste considering significant p摘要 背景：抗TNF药物是克罗恩病（Crohn’s disease, CD）治疗的核心组成部分，因此明确与抗TNF药物应答丢失相关的影响因素在临床实践中具有重要意义。研究目的：本研究旨在明确克罗恩病患者对抗TNF药物应答丢失的潜在相关因素。研究方法：本研究为前瞻性研究，纳入就诊于专科门诊的克罗恩病患者，采用专用表单收集数据，入组患者需满足接受抗TNF药物（英夫利昔单抗、阿达木单抗或赛妥珠单抗聚乙二醇酯）治疗且随访时长超过1年的条件。对所收集的信息进行制表与分析，以明确抗TNF药物应答丢失的潜在原因；研究结果采用卡方检验进行统计学分析，以具有统计学意义的P值为判定标准。