Time to kill estimated by the IC50 values of compounds 1, 2, 6 and 7 over 72 hours.
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The IC50 values for each compound were determined at 29, 48 and 72 hours following the addition of compound by a Presto Blue-based assay, over 2 experiments. The IC50 was also determined for the Alamar Blue-based HTS assay format. The positive control was puromycin and the reference compounds were puromycin and pentamidine.1Compound numbers refer to those outlined in Figure 5.
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2012-11-29



