Supplementary Material for: Integrative Assessment of Pretreatment Inflammation-, Nutrition-, and Muscle-Based Prognostic Markers in Patients with Muscle-Invasive Bladder Cancer Undergoing Radical Cystectomy

Objective: The present study evaluated the clinical relevance of an integrative preoperative assessment of inflammation-, nutrition-, and muscle-based markers for patients with muscle-invasive bladder cancer (MIBC) undergoing curative radical cystectomy (RC). Methods: The analysis enrolled 117 patients and the variables included age, body mass index (BMI), neutrophil-to-lymphocyte ratio, monocyte-to-lymphocyte ratio, platelet-to-lymphocyte ratio, modified Glasgow Prognostic Score (mGPS), prognostic nutritional index (PNI), Controlling Nutritional Status score, psoas muscle index (PMI), and peak expiratory flow (PEF). The correlations among the variables were evaluated and their prognostic values after RC were tested. Results: Three inflammation markers (ratios of blood cell counts) were positively correlated (p p = 0.04), although they were inversely correlated with the three inflammation markers (p Conclusions: The inflammation-, nutrition-, and muscle-based markers would be useful risk assessment tools for MIBC.研究目的：本研究旨在评估针对接受根治性膀胱切除术（radical cystectomy, RC）的肌层浸润性膀胱癌（muscle-invasive bladder cancer, MIBC）患者，整合炎症、营养及肌肉相关标志物的术前综合评估方案的临床相关性。 研究方法：本分析共纳入117例患者，纳入分析的变量包括年龄、体质量指数（body mass index, BMI）、中性粒细胞与淋巴细胞比值、单核细胞与淋巴细胞比值、血小板与淋巴细胞比值、改良格拉斯哥预后评分（modified Glasgow Prognostic Score, mGPS）、预后营养指数（prognostic nutritional index, PNI）、营养控制状态评分、腰大肌指数（psoas muscle index, PMI）以及峰值呼气流速（peak expiratory flow, PEF）。研究评估了各变量间的相关性，并检验了其在根治性膀胱切除术后的预后价值。 研究结果：三种炎症标志物（血细胞计数比值）呈正相关（原文此处p值标注疑似存在输入错误，仅见p = 0.04），且其与另外三种炎症标志物呈负相关（原文未完整给出对应p值）。 研究结论：炎症、营养及肌肉相关标志物可作为肌层浸润性膀胱癌患者有效的临床风险评估工具。