Table S1: Sex Differences in echocardiographic parameters

Serially measured echocardiographic parameters for three, (W3), six (W6), and ten (W10) week old WT and MLP-/- mice reported as mean ± SEM (N). The following markers denote statistically significant (p < 0.05) differences between these comparisons: ‘*’ WT group of the same age, ‘#’ the marked group and the corresponding W3 time point, ‘†’ the marked group and the corresponding W6 time point, ‘$’ the marked post-dobutamine parameter and the corresponding pre-dobutamine parameter of the same group. Pre-post dobutamine comparisons were only made between paired samples. ‘&’ denotes that comparisons between time points were not made due to attrition. Abbreviations: BW: body weight, ESV: end systolic volume, EDV: end diastolic volume, SV: stroke volume, HR: heart rate, ESD: end systolic diameter, EDD: end diastolic diameter, LV: left ventricular, PWTd: posterior wall thickness at diastole, EF: ejection fraction, FS: fractional shortening, DOB: dobutamine, Δ: difference between dobutamine and baseline values, PR: time between P and R waves, MVET: mitral valve ejection time, IVCT: isovolumic contraction time, IVRT: isovolumic relaxation time, AET: aortic ejection time, e’: peak mitral annulus velocity during early filling, a’: peak mitral annulus velocity during late filing, E: peak transmitral blood velocity during early filling, A: peak transmitral blood velocity during late filing, L: distance between apical and basal short axis images, GLS: global longitudinal strain, Pk; peak value, T2P; time to peak, SRS; systolic radial strain, SRSR; systolic radial strain rate, DRSR; diastolic radial strain rate.

本数据集包含3周龄（W3）、6周龄（W6）及10周龄（W10）野生型（WT）与MLP基因敲除（MLP-/-）小鼠的系列超声心动图检测参数，结果以均值±标准误（SEM）及对应样本量N形式报告。
以下符号代表组间比较具有统计学显著性差异（p < 0.05）：‘*’ 表示与同年龄野生型组的差异；‘#’ 表示标记组与对应W3时间点组的差异；‘†’ 表示标记组与对应W6时间点组的差异；‘$’ 表示标记组多巴酚丁胺干预后参数与同组干预前对应参数的差异。多巴酚丁胺干预前后的比较仅针对配对样本开展。‘&’ 表示因样本脱落未进行时间点间的比较。
缩写说明：BW（body weight）：体重；ESV（end systolic volume）：收缩末期容积；EDV（end diastolic volume）：舒张末期容积；SV（stroke volume）：每搏输出量；HR（heart rate）：心率；ESD（end systolic diameter）：收缩末期内径；EDD（end diastolic diameter）：舒张末期内径；LV（left ventricular）：左心室；PWTd（posterior wall thickness at diastole）：舒张期左心室后壁厚度；EF（ejection fraction）：射血分数；FS（fractional shortening）：短轴缩短率；DOB（dobutamine）：多巴酚丁胺；Δ：多巴酚丁胺干预值与基线值的差值；PR（time between P and R waves）：P-R间期；MVET（mitral valve ejection time）：二尖瓣射血时间；IVCT（isovolumic contraction time）：等容收缩时间；IVRT（isovolumic relaxation time）：等容舒张时间；AET（aortic ejection time）：主动脉射血时间；e’（peak mitral annulus velocity during early filling）：舒张早期二尖瓣环峰值运动速度；a’（peak mitral annulus velocity during late filling）：舒张晚期二尖瓣环峰值运动速度；E（peak transmitral blood velocity during early filling）：舒张早期经二尖瓣血流峰值速度；A（peak transmitral blood velocity during late filling）：舒张晚期经二尖瓣血流峰值速度；L（distance between apical and basal short axis images）：心尖与基底短轴切面间距；GLS（global longitudinal strain）：整体纵向应变；Pk（peak value）：峰值；T2P（time to peak）：达峰时间；SRS（systolic radial strain）：收缩期径向应变；SRSR（systolic radial strain rate）：收缩期径向应变率；DRSR（diastolic radial strain rate）：舒张期径向应变率。