HIF prolyl hydroxylase 2 (PHD2/ EGLN1) in complex with a Spiro[4.5]decanone inhibitor (JPHM-2-167)

HIF prolyl hydroxylase 2 (PHD2/ EGLN1) in complex with a Spiro[4.5]decanone inhibitor (JPHM-2-167) Descriptor: 8-[(3-methylpyridin-2-yl)methyl]-3-(4-phenylphenyl)-1-pyrimidin-2-yl-1,3,8-triazaspiro[4.5]decane-2,4-dione, Egl nine homolog 1, GLYCEROL, ... Authors: Chowdhury, R, Holt-Martyn, J.P, Rahman, M.Z, Schofield, C.J. Deposit date: 2019-01-13 Release date: 2020-02-05 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.4 Å) Cite: Studies on spiro[4.5]decanone prolyl hydroxylase domain inhibitors. Medchemcomm, 10, 2019

本数据集为HIF脯氨酰羟化酶2（HIF prolyl hydroxylase 2，PHD2/EGLN1）与螺[4.5]癸酮抑制剂（JPHM-2-167）的复合物。复合物描述：8-[(3-甲基吡啶-2-基)甲基]-3-(4-联苯基)-1-嘧啶-2-基-1,3,8-三氮杂螺[4.5]癸烷-2,4-二酮、Egl Nine同源物1（Egl nine homolog 1）、甘油（GLYCEROL）等。作者：Chowdhury R、Holt-Martyn J.P.、Rahman M.Z.、Schofield C.J.。提交日期：2019-01-13；发布日期：2020-02-05；最后修改日期：2024-01-24。实验方法：X射线衍射法，分辨率1.4埃（1.4 Å）。引用文献：《Studies on spiro[4.5]decanone prolyl hydroxylase domain inhibitors》，刊载于《Medchemcomm》，第10卷，2019年。