HVEM Gene Polymorphisms Are Associated with Sporadic Breast Cancer in Chinese Women

As a costimulatory molecule, Herpesvirus entry mediator (HVEM) can bind with several costimulatory members, thus HVEM plays different roles in T cell immunity. HVEM and its ligands have been involved in the pathogenesis of various autoimmune, inflammatory diseases and tumors. In the current study, we conducted a case-control study comparing polymorphisms of HVEM and breast cancer. Subjects included 575 females with breast cancer and 604 age-matched healthy controls. Six HVEM SNPs (rs2281852, rs1886730, rs2234163, rs11573979, rs2234165, and rs2234167) were genotyped by PCR-RFLP. The results showed significant differences in genotypes and alleles between rs1886730 and rs2234167 (P作为一种共刺激分子(costimulatory molecule)，疱疹病毒侵入介质(Herpesvirus entry mediator, HVEM)可与多种共刺激分子结合，因此HVEM在T细胞免疫中发挥不同的作用。HVEM及其配体已被证实参与多种自身免疫性、炎症性疾病及肿瘤的发病机制。本研究开展了一项病例对照研究(case-control study)，对比分析HVEM多态性与乳腺癌的关联。研究对象包括575名女性乳腺癌患者及604名年龄匹配的健康对照者。采用聚合酶链反应-限制性片段长度多态性(Polymerase Chain Reaction-Restriction Fragment Length Polymorphism, PCR-RFLP)技术，对6个HVEM单核苷酸多态性(Single Nucleotide Polymorphisms, SNPs)位点（rs2281852、rs1886730、rs2234163、rs11573979、rs2234165及rs2234167）进行基因分型。结果显示，rs1886730与rs2234167位点的基因型及等位基因频率存在显著差异（P