Structure of the GPR88-Gi1 signaling complex bound to a synthetic ligand

Structure of the GPR88-Gi1 signaling complex bound to a synthetic ligand Descriptor: (1R,2R)-N-[(2S,3S)-2-azanyl-3-methyl-pentyl]-N-[4-(4-propylphenyl)phenyl]-2-pyridin-2-yl-cyclopropane-1-carboxamide, CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... Authors: Xu, J, Chen, G, Liu, Z, Du, Y. Deposit date: 2021-04-02 Release date: 2022-04-13 Last modified: 2024-11-13 Method: ELECTRON MICROSCOPY (2.4 Å) Cite: Activation and allosteric regulation of the orphan GPR88-Gi1 signaling complex. Nat Commun, 13, 2022

结合合成配体的GPR88-Gi1信号复合物结构。描述项：(1R,2R)-N-[(2S,3S)-2-氨基-3-甲基戊基]-N-[4-(4-丙基苯基)苯基]-2-吡啶-2-基-环丙烷-1-甲酰胺、胆固醇、鸟苷酸结合蛋白G(I)/G(S)/G(O)亚基γ2等。作者：Xu, J、Chen, G、Liu, Z、Du, Y。存储日期：2021-04-02；发布日期：2022-04-13；最后修改日期：2024-11-13。解析方法：电子显微镜（分辨率2.4 Å）。引用文献：《孤儿GPR88-Gi1信号复合物的激活与变构调控》，《自然·通讯》，2022年，第13卷。