FDPS dimer transfers IPPP to DMAPP

The family of enzymes called prenyltransferases is involved in the biosynthesis of isoprenoids. Two members of this family are known to catalyse the sequential condensation of isopentenyl pyrophosphate (IPPP) to DMAPP: farnesyl pyrophosphate synthase dimer (FPPS dimer) and geranylgeranyl pyrophosphate synthetase hexamer (GGPPS hexamer) (Kavanaugh et al, 2006). Both enzymes utlise Mg2+ as cofactor (Chang et al. 2021).

酶家族中名为法尼基转移酶的成员，参与异戊二烯类生物合成过程。已知该家族中的两种成员催化异戊烯焦磷酸酯（IPPP）的连续缩合反应生成二甲基丙烯焦磷酸酯（DMAPP）：法尼基焦磷酸酯合酶二聚体（FPPS二聚体）和香叶基香叶基焦磷酸酯合酶六聚体（GGPPS六聚体）（Kavanaugh 等，2006年）。这两种酶均以Mg2+作为辅因子（Chang 等，2021年）。