Interleukin-23-induced transcription factor Blimp1 promotes pathogenicity of T helper 17 cells

ChEBI2016-06-15 更新2026-07-12 收录

Th17细胞调控

自身免疫性疾病

数据链接：

https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-GEOD-75724 数据链接链接失效反馈

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资源简介：

Interleukin-23-induced transcription factor Blimp1 promotes pathogenicity of T helper 17 cells

创建时间：

2016-06-15

Transcriptional profiling of human in vitro primed Th1, Th2, Th9 and Treg T cells. Transcriptional profiling of human in vitro primed Th1, Th2, Th9 and Treg T cells

T细胞亚群转录组学

自身免疫性疾病

To test whether human in vitro primed Th9 cells recapitulate the core pathogenic Th2 cell phenotype, we differentiated naïve T cells into Th1 (IL-12), Th2 (IL-4), Th9 (IL-4+TGF-β), and iTreg (TGF-β).

NIAID Data Ecosystem60

Transcription factor TCF1 binds Rorgt and orchestrates a regulatory network that determines homeostatic Th17 cell state [ATAC-seq]. Transcription factor TCF1 binds Rorgt and orchestrates a regulatory network that determines homeostatic Th17 cell state [ATAC-seq]

Th17细胞调控

染色质可及性分析

CD4+ T helper 17 (Th17) cells encompass a spectrum of cell states including homeostatic cells that maintain physiological functions such as barrier integrity and pathogenic cells that drive autoimmune

NIAID Data Ecosystem40

Data_Sheet_4_Lnc-ITSN1-2, Derived From RNA Sequencing, Correlates With Increased Disease Risk, Activity and Promotes CD4+ T Cell Activation, Proliferation and Th1/Th17 Cell Differentiation by Serving as a ceRNA for IL-23R via Sponging miR-125a in Inflammatory Bowel Disease.zip

结肠炎机制

Th17细胞调控

Background: This study aimed to investigate long-non-coding RNA (lncRNA) expression profiles and the correlation of lnc-ITSN1-2 expression with disease risk, activity and inflammation, and its influen

NIAID Data Ecosystem30

BET bromodomain inhibition suppresses TH17-mediated pathology. Mus musculus

Th17细胞调控

自身免疫疾病治疗

IL-17-producing T helper (TH17) cells have been selected through evolution for their ability to control fungal and bacterial infections. It is also firmly established that their aberrant generation an

NIAID Data Ecosystem50

Autoantibodies levels of subjects included in this study.

自身免疫性疾病

生物标志物检测

(XLSX)

NIAID Data Ecosystem30