gut microbiota

This study utilized the National Health and Nutrition Examination Survey (NHANES) 2007-2018 data, with 13,857 participants included in the final analysis after excluding patients with incomplete data. Probiotic, prebiotic, synbiotic, and yogurt supplements intakes, OBS values, depression levels, sleep disturbances, and cognitive function were assessed based on questionnaires and laboratory data. Logistic regression, mediation effects analysis, and COX regression modeling were employed to explore these supplements’ associations with OBS values in relation to mortality linked to depression, sleep disorders, and cognitive dysfunction.

本研究采用2007-2018年美国国家健康与营养检查调查（National Health and Nutrition Examination Survey, NHANES）数据集，在剔除数据不完整的受试者后，最终纳入13857名参与者开展最终分析。研究基于问卷与实验室检测数据，对受试者的益生菌、益生元、合生素及酸奶补充剂摄入情况、OBS值、抑郁水平、睡眠障碍与认知功能进行了评估。本研究采用逻辑回归、中介效应分析及COX回归建模方法，探究上述补充剂与OBS值的关联，及其与抑郁、睡眠障碍、认知功能障碍相关死亡的潜在联系。