PharmacotherapyDB 1.0: the open catalog of drug therapies for disease

This is the initial release of the PharmacotherapyDB, a catalog of drug therapies for disease. The catalog contains physician curated medical indications.<br>This release contains 97 diseases and 601 drugs. Between these drug–disease pairs, there are 755 disease-modifying therapies, 390 symptomatic therapies, and 243 non-indications. To enable integrative analyses, drugs and diseases are coded using DrugBank and Disease Ontology identifiers.<br>Indications were classified by physician curators into three categories:<code>DM</code> -- disease modifying<code>SYM</code> -- symptomatic<code>NOT</code> -- non-indication<br>This deposition contains the following files:<code>indications.tsv</code> contains drug–disease pairs and their consensus category (<code>DM</code>, <code>SYM</code>, or <code>NOT</code>). <code>n_curators</code> refers to how many of the three curators initially assigned the consensus classification. <code>n_resources</code> refers to how many of the four resources (MEDI-HPS, LabeledIn, EHRLink, PREDICT) included the indication.<code>diseases.tsv</code> contains a list of diseases with indications. For each disease, the number of indications per category is provided.<code>drugs.tsv</code> contains a list of drugs with indications. For each drug, the number of indications per category is provided.<code>catalog.xlsx</code> is a spreadsheet with four sheets:<code>indications</code> — data from <code>indications.tsv</code><code>diseases</code> — data from <code>diseases.tsv</code><code>drugs</code> — data from <code>drugs.tsv</code><code>curation</code> — the classifications from each of the three physician curators (<code>AJG</code>, <code>CSH</code>, &amp; <code>PK</code>).The catalog is released as CC0 1.0. However, please consider that the catalog includes DrugBank and DIsease Ontology identifiers and reference their licenses when appropriate.本文件为药物治疗数据库（PharmacotherapyDB）的首次发布版本，该数据库为针对疾病的药物治疗方案目录。本目录收录经医师人工审校的临床用药适应证。 本次发布版本共涵盖97种疾病与601种药物，其对应的药物-疾病关联中包含755种疾病修饰治疗药物、390种对症治疗药物以及243条非适应证条目。为支持整合性分析，本数据集采用DrugBank数据库（DrugBank）与疾病本体（Disease Ontology）标识符对药物及疾病进行编码。 经医师审校人员将适应证划分为三大类别：<code>DM</code>——疾病修饰治疗，<code>SYM</code>——对症治疗，<code>NOT</code>——非适应证。 本次提交包含以下文件： <code>indications.tsv</code>：收录药物-疾病关联条目及其共识分类（<code>DM</code>、<code>SYM</code>或<code>NOT</code>）。其中<code>n_curators</code>字段表示三位审校人员中最初达成共识分类的人数；<code>n_resources</code>字段则代表该适应证被收录的资源数量，本次共涉及4项资源：MEDI-HPS、LabeledIn、EHRLink及PREDICT。 <code>diseases.tsv</code>：收录拥有用药适应证的疾病列表，针对每种疾病，将按类别统计其对应的适应证数量。 <code>drugs.tsv</code>：收录拥有用药适应证的药物列表，针对每种药物，将按类别统计其对应的适应证数量。 <code>catalog.xlsx</code>：包含4个工作表的电子表格文件： <code>indications</code> —— 与<code>indications.tsv</code>的数据一致 <code>diseases</code> —— 与<code>diseases.tsv</code>的数据一致 <code>drugs</code> —— 与<code>drugs.tsv</code>的数据一致 <code>curation</code> —— 收录三位医师审校人员（<code>AJG</code>、<code>CSH</code>及<code>PK</code>）各自给出的分类结果。 本目录采用CC0 1.0协议发布。请注意，本目录包含DrugBank数据库（DrugBank）与疾病本体（Disease Ontology）的标识符，在适当场景下请参考对应资源的许可协议。