Single mutations decrease drug susceptibility and increase fitness.
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aGenotype; All strains are isogenic to MG1655 and carry only the mutations shown.bMIC for ciprofloxacin (��g/ml).cFitness; Mean fitness per generation (relative to wild-type). SD, standard deviation (within parentheses) measured in pair wise competition against the isogenic wild-type.dP; Significance of fitness difference between the strains in each pair, (Students t-test, two-tailed P-value).eN; Number of independent competition experiments on which the fitness value is based.
创建时间：
2015-12-02
