Supporting data and materials for "Large-scale analysis of evolutionary histories of phosphorylation motifs in the human genome".

Protein phosphorylation is a post-translational modification that is essential for a wide range of eukaryotic physiological processes, such as transcription, cytoskeletal regulation, cell metabolism, and signal transduction. In this study, we provide data for the assessments of functional phosphorylation signaling using comparative proteome analysis of phosphorylation motifs. Data for 93,101 phosphosites and 1,003,756 potential phosphosites are described and provide an overview of evolutionary patterns of phosphomotif acquisition and indicate dependence on motif structures. By using these data, we described interaction networks of phosphoproteins, identified kinase substrates associated with phosphoproteins, and performed gene ontology enrichment analyses.