Patient background.

Mixed connective tissue disease (MCTD) predominantly affects women in their reproductive age (30–40 years). This study is aimed to analyze a case series of MCTD-complicated pregnancies. The study design utilized a combined case-series and case–control approach. Pregnant women with MCTD were included and categorized into two groups: the live-birth and non-live birth (encompassing miscarriages at p = 0.02) and lower prednisolone dosage in the live birth group (median dose: 7 vs. 10 mg, p = 0.03) were found to be significant factors contributing to live births. MCTD during pregnancy was associated with increased risks of miscarriage, stillbirth, preterm delivery, FGR, and SGA. Notably, low-dose steroid therapy was identified as a contributing factor to successful live births.混合性结缔组织病（MCTD）主要累及生育年龄（30~40岁）的女性。本研究旨在分析一组合并MCTD的妊娠病例序列。研究采用病例序列与病例对照相结合的设计方案。本研究纳入合并MCTD的妊娠女性，并将其分为活产组与非活产组两组（非活产组包含流产病例，关联P值为0.02）；研究发现，活产组患者的泼尼松龙（prednisolone）中位剂量仅为7mg，显著低于非活产组的10mg（P=0.03），该剂量差异是影响活产结局的显著相关因素。妊娠合并MCTD与流产、死胎、早产、胎儿生长受限（Fetal Growth Restriction, FGR）以及小于胎龄儿（Small for Gestational Age, SGA）的发病风险升高显著相关。值得注意的是，低剂量糖皮质激素治疗被证实是提升活产成功率的相关因素。