Effect of coenzyme Q10 on post-extraction tissue healing in wisdom tooth Surgery: double-blind randomized clinical trial

This study primarily aimed to evaluate the efficacy of Coenzyme Q10 supplementation in improving post-extraction tissue healing and, secondarily, its effects on reducing temporomandibular disorders (TMD), dry socket and enhancing quality of life following wisdom tooth extraction. This parallel randomized, double-blind, placebo-controlled trial included 70 participants, randomly assigned to receive either CoQ10 or placebo. The primary outcome was tissue healing, measured by clinical assessments on days 7, 14 and 30 post-surgeries; alongside secondary outcomes including the occurrence of TMD and dry socket occurrence. Additional secondary outcomes included physical and psychological recovery, assessed using the 36-item short form survey (SF36) and the 12-item general health questionnaire (GHQ12), which measure psychological distress and health-related quality of life. On day 7, the CoQ10 group showed a significant 45% improvement in tissue healing, compared to its counterpart and by day 14, showed a 55% improvement. TMD occurred in 12% of the CoQ10 group vs. 30% in the placebo group; and dry socket was 6% in the CoQ10 group vs. 18% in the placebo group. Coenzyme Q10 supplementation significantly accelerates tissue healing, reduces TMD and dry socket incidence and improves physical and mental health outcomes following wisdom tooth extraction. ClinicalTrials.gov [registration number NCT06452134] Improved Recovery Following Wisdom Tooth Removal Using Coenzyme Q10 This study looked at whether a daily Coenzyme Q10 supplement may help patients heal faster and lower typical problems following wisdom teeth removal. Two groups – randomly split from 70 patients – were formed. One group received a placebo; another took 100 mg of Coenzyme Q10 daily for 30 days. Following surgery, researchers examined recovery at 7, 14, and 30 days. They also noted difficulties including dry socket – a painful condition in which the blood clot in the tooth socket dissolves – and jaw joint abnormalities – temporomandibular disorder, or TMD. Furthermore, the study gauged general mental health as well as physical healing using straight forward questionnaires. With fewer cases of dry socket and TMD compared to the placebo group, the findings revealed that patients using Coenzyme Q10 healed their tissues faster. They also reported higher ratings for emotional well-being and physical functioning. These results suggest that Coenzyme Q10 not only accelerates healing but also improves overall recovery and quality of life following the wisdom tooth extraction. All things considered, Coenzyme Q10 seems to be a safe and efficient addition to assist in faster healing following wisdom teeth extraction and help to lower problems.

本研究首要目标为评估补充辅酶Q10（Coenzyme Q10）对智齿拔除术后组织愈合的改善效果，次要目标为探究其对降低颞下颌关节紊乱病（Temporomandibular Disorders, TMD）、干槽症（dry socket）发生率，以及提升智齿拔除术后患者生活质量的作用。本研究为平行随机双盲安慰剂对照试验（parallel randomized, double-blind, placebo-controlled trial），共纳入70名受试者，随机分配至辅酶Q10组与安慰剂组。主要结局指标为组织愈合情况，分别于术后第7、14、30天通过临床评估进行测定；次要结局指标包括颞下颌关节紊乱病与干槽症的发生情况。额外次要结局指标涵盖躯体与心理恢复状况，采用36条目简明健康调查问卷（36-item Short Form Survey, SF36）与12条目一般健康问卷（12-item General Health Questionnaire, GHQ12）进行评估，二者分别用于衡量心理困扰程度与健康相关生活质量。术后第7天，辅酶Q10组的组织愈合情况较安慰剂组显著提升45%；至术后第14天，该组愈合改善幅度达55%。颞下颌关节紊乱病在辅酶Q10组中的发生率为12%，安慰剂组则为30%；干槽症在辅酶Q10组发生率为6%，安慰剂组为18%。研究结果表明，补充辅酶Q10可显著加速智齿拔除术后的组织愈合，降低颞下颌关节紊乱病与干槽症的发生率，并改善患者术后的躯体与心理健康结局。本研究已在临床试验.gov（ClinicalTrials.gov）完成注册，注册号为NCT06452134。

《智齿拔除术后应用辅酶Q10促进恢复》本研究探讨了每日补充辅酶Q10是否可帮助患者更快愈合，并降低智齿拔除术后常见并发症。研究将70名患者随机分为两组：一组接受安慰剂治疗，另一组每日服用100mg辅酶Q10，持续30天。术后，研究者分别于第7、14、30天评估患者恢复情况，并记录干槽症——一种因牙槽窝内血凝块溶解引发的疼痛病症——与颞下颌关节异常（即颞下颌关节紊乱病，TMD）等并发症发生情况。此外，本研究通过简易问卷评估患者整体心理健康状况与躯体愈合水平。与安慰剂组相比，辅酶Q10组患者的干槽症与颞下颌关节紊乱病发生率更低，组织愈合速度更快，且其情绪健康与躯体功能评分更高。上述结果提示，辅酶Q10不仅可加速智齿拔除术后的愈合进程，还可改善患者术后整体恢复状况与生活质量。综合来看，辅酶Q10作为辅助干预手段，可安全有效地促进智齿拔除术后快速愈合，并降低相关并发症风险。