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Single cell transcriptomic analysis reveals cellular diversity of murine esophageal epithelium and age-associated mitochondrial dysfunction.

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We have performed single cell RNA-sequencing to characterize the murine esophageal epithelium in young and aged mice. We used peeled esophageal epithelium from young (<=4 months) and aged ( >=18 months) mice to investigate the molecular heterogeneity of the esophageal epithelium at single cell resolution.

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