Visible-Light Induced Isoindoles Formation To Trigger Intermolecular Diels–Alder Reactions in the Presence of Air

Visible-light induced isoindole formation triggered an intermolecular Diels–Alder reaction with dienophiles such as acetylenedicarboxylate and maleimides in the presence of air. The reaction resulted in excellent diastereoselctivity and high yields under mild reaction conditions. This protocol provides an atom-economical, transition-metal-free (TM-free) and straightforward approach to structurally diverse bridged-ring heterocycles from easily accessible molecules.可见光诱导异吲哚生成后，可在空气氛围下与乙炔二羧酸酯、马来酰亚胺等亲双烯体发生分子间狄尔斯-阿尔德（Diels–Alder）反应。该反应在温和反应条件下可获得优异的非对映选择性与较高产率。此合成策略无需过渡金属（TM-free），具备原子经济性，能够从易得原料出发，简洁高效地构建结构多样的桥环杂环化合物。