Regulation of PRC2.2 by its nucleic acid-binding subunits

Polycomb repressive complex 2 (PRC2) is a protein complex responsible for ensuring certain genes are “switched off” at crucial points of human development when their product is not needed. There are many biological molecules that can regulate PRC2 to ensure it appropriately performs its role, such as DNA, RNA, and specific “accessory” proteins of PRC2. Dysregulation of PRC2 can lead to disease states such as cancer and certain developmental syndromes. During my PhD, I aimed to improve our understanding of how binding with RNA and DNA can regulate PRC2, specifically when PRC2 is with its accessory proteins AEBP2 and JARID2.