Differences in the neural basis and transcriptomic patterns in acute and persistent pain-related anxiety-like behaviors

To investigate the different mechanism of Formalin induced acute pain and CFA induced persistent pain in mPFC and BNST, mice were treated by Formalin exposure or CFA exposure or without treatment and their mPFC and BNST were dissected to perform RNA seq. Overall design: Comparative gene expression profiling analysis of RNA-seq data for mPFC and BNST under different treatment (no treatment as control, Formalin exposure and CFA exposure).