Additional file 6 of Epigenetic instability caused by absence of CIZ1 drives transformation during quiescence cycles

Additional file 6: SDataset 5. Excel file showing mean data and the size of change with significance indicators for all transcription units from the curated gene set “M149, Fischer DREAM targets” that are inappropriately downregulated in CIZ1-null PEFs during entry to quiescence by both methods (serum withdrawal and contact inhibition). The three transcription units relating to gene ids; XLOC_007113, XLOC_012670 and XLOC_028106 were removed from analysis due to other gene names mapping to the same locus. This creates the list of 33 genes. Sheet 2, GSEA output for the 33 IDN dream target genes in Sheet 1 and their overlap with GO terms. Additional sheets show the same data for the second (Lee BMP2 targets DN), third (Marson bound by E2F4 unstimulated), fourth (Gobert oligodendrocyte differentiation UP) and fifth (Zhang TLX targets 60hr DN) most significant overlapping gene sets (related to Fig. 2H).

附加文件6：数据集5（SDataset 5）。本Excel文件展示了经人工注释的基因集“M149、Fischer DREAM靶标”中，在CIZ1敲除的猪胚胎成纤维细胞（PEFs）通过血清剥夺与接触抑制两种方法进入细胞静息状态时出现异常下调的所有转录单元的均值数据、变化幅度及显著性检验指标。由于存在其他基因名称映射至同一基因座的情况，编号为XLOC_007113、XLOC_012670及XLOC_028106的3个转录单元被剔除出本次分析，最终得到包含33个基因的分析列表。第2工作表包含第1工作表中33个DREAM靶基因的基因集富集分析（GSEA）结果，以及这些基因与基因本体（GO）术语的重叠分布情况。其余工作表则展示了第2至第5个最显著重叠基因集的同类数据，分别为：第二个（Lee团队骨形态发生蛋白2（BMP2）下调靶基因集）、第三个（未受刺激状态下结合转录因子E2F4（E2F4）的Marson靶基因集）、第四个（Gobert团队少突胶质细胞分化上调基因集）及第五个（Zhang团队TLX靶基因60小时下调组），相关内容对应图2H。