Vertebral fusion anomalies in Nf1flox/flox and Nf1flox/−;PeriCre and Col2.3 mice.

Anterior-posterior and lateral radiographs of WT (n = 29), Nf1+/− (n = 18), Nf1flox/flox;PeriCre (n = 46), Nf1flox/−;PeriCre (n = 41), Nf1flox/flox;Col2.3Cre (n = 15), and Nf1flox/−;Col2.3Cre (n = 20) mice were acquired to screen for the presence of vertebral fusion anomalies. The percentage of mice exhibiting vertebral fusion defects as well as the frequency distribution of the affected segments are summarized in the table and pie chart below.*Fusion present at L4–5 in all 4 mice**Fusion present at multiple spinal levels: T13-L1 = 2 mice, L1–2 = 1 mouse, L3–4 = 3 mice, L4–5 = 6 mice, L5–6 = 2 mice, L6-S1 = 1 mouse#Fusion present at L4–5 in 1 mouse##Fusion present at multiple spinal levels: T10–12 = 1 mouse, T12–13 = 2 mice, L2–3 = 2 mice, L3–4 = 3 mice, L4–5 = 3 mice, L5–6 = 1 mouseVertebral fusion anomalies in Nf1flox/flox and Nf1flox/−;PeriCre and Col2.3 mice.本研究获取了野生型（Wild Type, WT，n=29）、Nf1+/−（n=18）、Nf1flox/flox;PeriCre（n=46）、Nf1flox/-;PeriCre（n=41）、Nf1flox/flox;Col2.3Cre（n=15）以及Nf1flox/-;Col2.3Cre（n=20）小鼠的前后位及侧位X线片，以筛查椎体融合异常的发生情况。 出现椎体融合缺陷的小鼠比例，以及受影响脊柱节段的频率分布，已汇总于下表及下方饼图中。 * 4只小鼠均在L4-L5节段出现椎体融合 ** 多脊柱节段融合：T13-L1节段2只、L1-L2节段1只、L3-L4节段3只、L4-L5节段6只、L5-L6节段2只、L6-S1节段1只 # 1只小鼠在L4-L5节段出现椎体融合 ## 多脊柱节段融合：T10-T12节段1只、T12-T13节段2只、L2-L3节段2只、L3-L4节段3只、L4-L5节段3只、L5-L6节段1只 本数据集涵盖Nf1flox/flox、Nf1flox/-;PeriCre及Col2.3Cre小鼠的椎体融合异常相关数据。