Single-cell atlas of the first intra-mammalian developmental stage of the human parasite Schistosoma mansoni

Over 250 million people suffer from schistosomiasis, a tropical disease caused by parasitic flatworms known as schistosomes. To unravel the transcriptional signatures for the larval stage of this parasite, we perform single-cell RNA sequencing on two-day old schistosomula. We described 15 populations and spatially validated our results using FISH.