Maintaining centromere integrity is crucial for genome stability and proper chromosome segregation during mitosis. CENPA, a conserved histone H3 variant, is localized at the centromeres and plays an e

NIAID Data Ecosystem10

Long Term Transcriptional Reactivation of Epigenetically Silenced Genes in Colorectal Cancer Cells Requires DNA Hypomethylation and Histone Acetylation

癌症表观遗传学

基因再激活机制

Epigenetic regulation of genes involves the coordination of DNA methylation and histone modifications to maintain transcriptional status. These two features are frequently disrupted in malignancy such

Figshare2016-01-18 更新10

Mapping Context-Aware Phosphosite Regulation of Protein–Protein Interactions Using Deep Learning and Pan-Cancer Proteomics

磷酸化位点调控蛋白互作预测

癌症表观遗传学

Phosphorylation dynamically orchestrates the protein–protein interaction (PPI) network that governs cellular signaling, and its dysregulation frequently drives malignant transformation and neurodegene

NIAID Data Ecosystem30

Additional file 13 of Pan-cancer analysis revealed H3K4me1 at bivalent promoters premarks DNA hypermethylation during tumor development and identified the regulatory role of DNA methylation in relation to histone modifications

癌症表观遗传学

甲基化调控基因

Additional file 13: Supplementary Table S1. Summary of 5 gene groups in different cancer types.

Figshare2024-02-14 更新10