Lobular carcinoma, NOS - Female, 73 - Tissue image [6060730023685071]

This is the histopathological image of BREAST tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format. The detailed information about the patient, sample, and diagnosis are as follows: Patient:Age: 73Clinical description: Palpable tumor of right breast. 12 mm hypoechoic spicular tumor on ultrasound.Gender: FemaleDiagnosis:Classification: ICD-O_3.2Classification code: DUCTAL AND LOBULAR NEOPLASMSDiagnosis: Lobular carcinoma, NOSResult of the histopathological examination: Lobular carcinoma of breast (e-cadherin-) NHG2 (3+2+1: 0 mitoses/10 HPF): ER+, PR-, HER2 1, Ki-67 7%. Lobular neoplasia is present.Sample:Material: FFPECollecting method: Core-needle biopsyTopography: BREASTOrgan: BREASTTissue: Breast, NOSType of staining: positive/IHCStaining: Not applicableAntibody: ERTechnology:Equipment: Pannoramic 250 3DHistechLens: 20xOrganization:Source: Medical University Gdańsk

本数据集为格但斯克医科大学（Medical University Gdańsk）采集并存入ZMDL-GUMED数据库的乳腺组织样本组织病理图像。该样本图像采用Pannoramic 250 3DHistech玻片扫描仪以20倍放大倍数采集，存储为数字成像与通信医学格式（Digital Imaging and Communications in Medicine, DICOM）。

患者与样本详细信息如下：
### 患者与诊断详情
1. 患者基本信息：年龄73岁，女性；临床特征为右侧乳腺可触及肿块，超声检查可见12mm低回声毛刺状肿瘤。
2. 诊断分类：ICD-O_3.2分类编码为导管及小叶上皮肿瘤（DUCTAL AND LOBULAR NEOPLASMS）；最终诊断为非特指型小叶癌（Lobular carcinoma, NOS）。
3. 组织病理检查结果：乳腺小叶癌（E-钙粘蛋白阴性[e-cadherin-]），组织学分级NHG2（核分级3分+腺管形成2分+核多形性1分，每10个高倍视野(High Power Field, HPF)核分裂象为0个）；免疫组化检测结果：雌激素受体(Estrogen Receptor, ER)阳性、孕激素受体(Progesterone Receptor, PR)阴性、人表皮生长因子受体2(Human Epidermal Growth Factor Receptor 2, HER2)1+、Ki-67增殖指数为7%；可见小叶肿瘤性病变。

### 样本参数
样本材料：福尔马林固定石蜡包埋（Formalin-Fixed Paraffin-Embedded, FFPE）样本
采集方式：粗针穿刺活检
病变部位：乳腺
所属器官：乳腺
组织类型：乳腺，非特指型（NOS）
染色类型：免疫组化（Immunohistochemistry, IHC）阳性染色
染色要求：无特殊适用方案
所用抗体：ER

### 成像与提供机构
成像设备：Pannoramic 250 3DHistech玻片扫描仪
镜头放大倍数：20倍
数据提供机构：格但斯克医科大学（Medical University Gdańsk）