Inhibition of calculi forming oxalate by dietary Basella rubra organs: Litholytic activity

Abstract The inhibition of calculi forming oxalate by dietary Basella rubra plant organs leaf and stem pod has been investigated. The weight reduction assay was studied. Also a concoction of the plant organs was tested. Leaf extract was found with considerable activity whereas the concoction seems to be not much active as the stem pod extract. Soluble oxalate of the plant organs are partially removed prior to extraction of active constituents. The active component/s seem to be a non-protein and non-tannin molecule/s that may act through inhibition of calcium accumulation there by proving the positive activity against the calculi or kidney stone. Regular consumption of leaf and stem pod extracts of our plant would be helpful in calculi prophylaxis.

摘要 本研究探讨了膳食用落葵（Basella rubra）的不同器官（叶片、茎荚）对草酸结石形成的抑制作用。研究采用重量减量实验法开展相关分析，并对该植物器官的混合提取物进行了活性测试。结果显示，叶片提取物具备显著的抗结石活性，而混合提取物的活性则远不及茎荚提取物。在提取活性成分前，已预先对植物器官中的可溶性草酸进行了部分脱除。该活性成分为非蛋白、非鞣质类分子，其作用机制可能通过抑制钙积累，从而发挥抗结石或肾结石的防护活性。日常适量摄入该植物的叶片与茎荚提取物，有助于草酸结石的预防。