The miR-29-IFN-?-JAK-STAT axis attenuates CD8+ T cell overactivation and differentiation in ulcerative colitis, and delivery of mimics in LMSH-CS hydrogel reduces colitis in mice

To investigate the mechanism of miR-29ab in regulation of Tcells , we established miR-29ab1-/- mice and applied dss inflammation model Overall design: We then performed gene expression profiling analysis using data obtained from RNA-seq of colon yissue from WT and miR-29ab1-/- mice before and after DSS. Comparative gene expression profiling analysis of RNA-seq data for WT and miR-29ab1-/- mice.