Supplementary Material for: The Relationship of NT-proBNP and Dialysis Parameters with Outcome of Incident Haemodialysis Patients: Results from the Membrane Permeability Outcome Study

<b><i>Background/Aims:</i></b> The association of raised levels of natriuretic peptides with elevated risk of mortality was investigated in the present analysis of the Membrane Permeability Outcome study. <b><i>Methods:</i></b> N-terminal probrain type natriuretic peptide (NT-proBNP) was measured in 618 incident haemodialysis patients, randomised to either high-flux or low-flux. Characteristics of patients with NT-proBNP levels below or above the median were descriptively analysed and survival analysis was performed. <b><i>Results:</i></b> Median NT-proBNP value was 2,124 pg/ml, with 1,854 pg/ml in the high-flux and 2,919 pg/ml in the low-flux group. Survival probability was lowest in patients with both a history of cardiovascular disease and NT-proBNP values above the median (p &lt; 0.001). A multivariate Cox proportional hazard model showed interaction between presence of cardiovascular diseases and NT-proBNP levels above the median. <b><i>Conclusions:</i></b> NT-proBNP is an independent predictor of mortality also in incident haemodialysis patients. Lower concentrations associated with high-flux dialysis suggest a possible biological link to improved survival in this group.

**背景与目的**：本研究针对膜通透性结局（Membrane Permeability Outcome）研究开展分析，旨在探讨利钠肽水平升高与死亡风险升高之间的关联。
**方法**：本研究对618例新发血液透析患者的N末端B型利钠肽原（NT-proBNP）水平进行检测，所有受试者被随机分配至高通量透析组或低通量透析组。研究对NT-proBNP水平低于或高于中位数的患者的临床特征进行描述性分析，并开展生存分析。
**结果**：本次研究中NT-proBNP的中位数为2124 pg/ml，其中高通量透析组为1854 pg/ml，低通量透析组为2919 pg/ml。同时合并心血管疾病病史且NT-proBNP水平高于中位数的患者，其生存概率最低（p < 0.001）。多因素Cox比例风险回归模型分析结果显示，心血管疾病病史与NT-proBNP水平高于中位数之间存在交互作用。
**结论**：NT-proBNP可作为新发血液透析患者死亡风险的独立预测因子。高通量透析患者较低的NT-proBNP水平提示，该群体的生存状况改善可能与之存在生物学关联。