Follow_up_studies_in_Africa_of_both_Typhoidal_and_non_typhoidal_Salmonella_infections

The rise of Non-Typhoidal Salmonella infections (NTS) continues to cause health problems in many African countries. It is important that the continuing isolation of NTS infections is carefully monitored to identify any new trends or properties as well as changes in the clinical manifestations and any co-localisation with other pathogens. We also aim to follow the continuing isolation of Typhoidal outbreaks that are also being recovered so follow plasmids and resistance profiles along with other potential changes in the genome content. These present studies focus on samples obtained from Uganda, Kenya, Burkina Faso and Ghana. The study plans to examine, via illumine, 230 samples obtained from hospitals in these countries, usually from blood cultures.非伤寒沙门氏菌感染（Non-Typhoidal Salmonella infections, NTS）的持续流行，仍在诸多非洲国家引发公共健康问题。对NTS感染的临床分离株开展严格监测，以识别新型流行趋势、菌株特性变化、临床表现改变，以及与其他病原体的共定植现象，这一工作至关重要。本研究同时针对当前分离获得的伤寒型沙门氏菌暴发株展开追踪，对其携带的质粒、耐药谱以及基因组组成的其他潜在变化进行分析。本次研究的样本取自乌干达、肯尼亚、布基纳法索与加纳四国，计划通过Illumina测序技术，对上述国家医院采集的230份通常为血液培养的样本进行检测分析。