Ctla-4 Immunization

The purpose of these experiments was to determine whether expansion in the observed T cell phenotypes in Ctla-4 knockout mice were due to uncontrolled proliferation. To address this possibility, Ctla-4 knockout mice and littermate control mice were randomized to unimmunized or immunized groups (Ova in CFA) and analyzed using mass cytometry panels designed to deeply interrogate T cell activation status and differentiation.
Notes:
DOI:https://doi.org/10.1016/j.immuni.2019.03.004 Mouse ID Genotype Note D117 Het Non-imm D118 WT Immunized D119 WT Non-imm D120 WT Immunized D122 WT Immunized D123 WT Non-imm D124 KO Non-imm D125 Het Immunized D126 KO Immunized D127 KO Non-imm D128 Het Non-imm D129 WT Immunized D130 WT Non-imm D131 Het Non-imm D132 WT Immunized D133 KO Non-imm D134 KO Non-imm D135 KO Immunized D136 Het Non-imm D137 Het Immunized